Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting NF-&#954;B pathway in vitro and in vivo.

Wang, Wei; Wang, Shou-Kai; Wang, Qi; Zhang, Zhe; Li, Bo; Zhou, Zi-Dan; Zhang, Jian-Feng; Lin, Chao; Chen, Ting-Xiao; Jin, Zhen; Tang, You-Zhi

Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting NF-κB pathway in vitro and in vivo.

Wang, Wei; Wang, Shou-Kai; Wang, Qi; Zhang, Zhe; Li, Bo; Zhou, Zi-Dan; Zhang, Jian-Feng; Lin, Chao; Chen, Ting-Xiao; Jin, Zhen; Tang, You-Zhi.

Afiliação

Wang W; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Wang SK; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Wang Q; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Zhang Z; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Li B; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Zhou ZD; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Zhang JF; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Lin C; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Chen TX; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Jin Z; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Tang YZ; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China. Electronic address: youzhit

Eur J Med Chem ; 259: 115669, 2023 Nov 05.

Article em En | MEDLINE | ID: mdl-37517204

Assuntos

Diclofenaco; NF-kappa B; Animais; Camundongos; Ratos; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Diclofenaco/farmacologia; Diclofenaco/uso terapêutico; Eugenol/farmacologia; Eugenol/uso terapêutico; Heme Oxigenase-1/efeitos dos fármacos; Heme Oxigenase-1/metabolismo; Lipopolissacarídeos/farmacologia; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/metabolismo; Células RAW 264.7

Palavras-chave

Anti-inflammation; Diclofenac-eugenol hybrid; Gastric ulcer; Heme oxygenase-1; NF-κB p65; Ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diclofenaco / NF-kappa B Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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