Melatonin: A look at protozoal and helminths.
Biochimie
; 219: 96-109, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37541568
ABSTRACT
Melatonin is a pleiotropic neurohormone found in different animal, plant, and microorganism species. It is a product resulting from tryptophan metabolism in the pineal gland and is widely known for its ability to synchronize the circadian rhythm to antitumor functions in different types of cancers. The molecular mechanisms responsible for its immunomodulatory, antioxidant and cytoprotective effects involve binding to high-affinity G protein-coupled receptors and interactions with intracellular targets that modulate signal transduction pathways. In vitro and in vivo studies have reported the therapeutic potential of melatonin in different infectious and parasitic diseases. In this review, the protective and pathophysiological roles of melatonin in fighting protozoan and helminth infections and the possible mechanisms involved against these stressors will be discussed.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Parasitárias
/
Glândula Pineal
/
Helmintos
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Melatonina
Limite:
Animals
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2024
Tipo de documento:
Article