Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase 1b, Open-Label, Single-Dose Clinical Trial.

Bradley, John S; Makieieva, Nataliia; Tøndel, Camilla; Roilides, Emmanuel; Kelly, Matthew S; Patel, Munjal; Vaddady, Pavan; Maniar, Alok; Zhang, Ying; Paschke, Amanda; Chen, Luke F

Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase 1b, Open-Label, Single-Dose Clinical Trial.

Bradley, John S; Makieieva, Nataliia; Tøndel, Camilla; Roilides, Emmanuel; Kelly, Matthew S; Patel, Munjal; Vaddady, Pavan; Maniar, Alok; Zhang, Ying; Paschke, Amanda; Chen, Luke F.

Afiliação

Bradley JS; Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital of San Diego, San Diego, CA, USA.
Makieieva N; Department of Pediatrics, Kharkiv National Medical University, Kharkiv, Ukraine.
Tøndel C; Department of Clinical Science, University of Bergen, and Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
Roilides E; Third Department of Pediatrics, Infectious Diseases Unit, School of Medicine, Aristotle University and Hippokration General Hospital, Thessaloniki, Greece.
Kelly MS; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Patel M; Merck & Co. Inc, Rahway, NJ, USA.
Vaddady P; Merck & Co. Inc, Rahway, NJ, USA.
Maniar A; Daiichi Sankyo, Inc., Basking Ridge, NJ, USA.
Zhang Y; Merck & Co. Inc, Rahway, NJ, USA.
Paschke A; Merck & Co. Inc, Rahway, NJ, USA.
Chen LF; Merck & Co. Inc, Rahway, NJ, USA.

J Clin Pharmacol ; 63(12): 1387-1397, 2023 12.

Article em En | MEDLINE | ID: mdl-37562063

Assuntos

Infecções Bacterianas; Infecções por Bactérias Gram-Negativas; Adulto; Criança; Humanos; Imipenem/farmacocinética; Cilastatina/efeitos adversos; Cilastatina/farmacocinética; Antibacterianos; Compostos Azabicíclicos/efeitos adversos; Combinação de Medicamentos; Infecções por Bactérias Gram-Negativas/tratamento farmacológico; Testes de Sensibilidade Microbiana; Infecções Bacterianas/tratamento farmacológico

Palavras-chave

carbapenem/ß-lactamase inhibitor; children; dose selection; gram-negative bacterial infection; imipenem/cilastatin/relebactam

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Bacterianas / Infecções por Bactérias Gram-Negativas Limite: Adult / Child / Humans Idioma: En Revista: J Clin Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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