Ruthenium metallodendrimer against triple-negative breast cancer in mice.

Michlewska, Sylwia; Wójkowska, Dagmara; Watala, Cezary; Skiba, Elzbieta; Ortega, Paula; de la Mata, Francisco Javier; Bryszewska, Maria; Ionov, Maksim

Michlewska, Sylwia; Wójkowska, Dagmara; Watala, Cezary; Skiba, Elzbieta; Ortega, Paula; de la Mata, Francisco Javier; Bryszewska, Maria; Ionov, Maksim.

Afiliação

Michlewska S; Laboratory of Microscopic Imaging and Specialized Biological Techniques, Faculty of Biology and Environmental Protection, University of Lodz, Poland; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland. Electronic address: sylwia.michlewska@b
Wójkowska D; Department of Haemostatic Disorders, Faculty of Health Sciences, Medical University of Lodz, Poland.
Watala C; Department of Haemostatic Disorders, Faculty of Health Sciences, Medical University of Lodz, Poland.
Skiba E; Institute of General and Ecological Chemistry, Lodz University of Technology, Poland.
Ortega P; Universidad de Alcalá, Department of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Madrid, Spain; Instituto de Investigación Sanitaria Ramón y Cajal, IRYCIS, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),
de la Mata FJ; Universidad de Alcalá, Department of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Madrid, Spain; Instituto de Investigación Sanitaria Ramón y Cajal, IRYCIS, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),
Bryszewska M; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland.
Ionov M; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland.

Nanomedicine ; 53: 102703, 2023 09.

Article em En | MEDLINE | ID: mdl-37591367

ABSTRACT

ABSTRACT

Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivo investigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICP analyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour.

Assuntos

Antineoplásicos; Rutênio; Neoplasias de Mama Triplo Negativas; Humanos; Animais; Camundongos; Rutênio/farmacologia; Rutênio/uso terapêutico; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/patologia; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Linhagem Celular Tumoral

Palavras-chave

Anticancer agent; In vivo; Ruthenium metallodendrimer; Toxicity; Tumour weight

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Neoplasias de Mama Triplo Negativas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Nanomedicine Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2023 Tipo de documento: Article

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