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Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
Cheong, Jin-Gyu; Ravishankar, Arjun; Sharma, Siddhartha; Parkhurst, Christopher N; Grassmann, Simon A; Wingert, Claire K; Laurent, Paoline; Ma, Sai; Paddock, Lucinda; Miranda, Isabella C; Karakaslar, Emin Onur; Nehar-Belaid, Djamel; Thibodeau, Asa; Bale, Michael J; Kartha, Vinay K; Yee, Jim K; Mays, Minh Y; Jiang, Chenyang; Daman, Andrew W; Martinez de Paz, Alexia; Ahimovic, Dughan; Ramos, Victor; Lercher, Alexander; Nielsen, Erik; Alvarez-Mulett, Sergio; Zheng, Ling; Earl, Andrew; Yallowitz, Alisha; Robbins, Lexi; LaFond, Elyse; Weidman, Karissa L; Racine-Brzostek, Sabrina; Yang, He S; Price, David R; Leyre, Louise; Rendeiro, André F; Ravichandran, Hiranmayi; Kim, Junbum; Borczuk, Alain C; Rice, Charles M; Jones, R Brad; Schenck, Edward J; Kaner, Robert J; Chadburn, Amy; Zhao, Zhen; Pascual, Virginia; Elemento, Olivier; Schwartz, Robert E; Buenrostro, Jason D; Niec, Rachel E.
Afiliação
  • Cheong JG; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA.
  • Ravishankar A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Sharma S; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Parkhurst CN; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Grassmann SA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Wingert CK; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Laurent P; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.
  • Ma S; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02142, USA.
  • Paddock L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Miranda IC; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Karakaslar EO; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Leiden University Medical Center (LUMC), Leiden, The Netherlands.
  • Nehar-Belaid D; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Thibodeau A; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Bale MJ; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA.
  • Kartha VK; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02142, USA.
  • Yee JK; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Mays MY; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Jiang C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Daman AW; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA.
  • Martinez de Paz A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Ahimovic D; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA.
  • Ramos V; The Rockefeller University, New York, NY 10065, USA.
  • Lercher A; The Rockefeller University, New York, NY 10065, USA.
  • Nielsen E; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Alvarez-Mulett S; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Zheng L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Earl A; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02142, USA.
  • Yallowitz A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Robbins L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • LaFond E; NYU Langone Health, New York, NY 10016, USA.
  • Weidman KL; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Racine-Brzostek S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Yang HS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Price DR; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Leyre L; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA.
  • Rendeiro AF; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA; CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, 1090 Vienna, Austria.
  • Ravichandran H; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.
  • Kim J; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Borczuk AC; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pathology and Laboratory Medicine, Northwell Health, Greenvale, NY 11548, USA.
  • Rice CM; The Rockefeller University, New York, NY 10065, USA.
  • Jones RB; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY 10065, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.
  • Schenck EJ; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Kaner RJ; Department of Genetic Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Chadburn A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Zhao Z; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Pascual V; Department of Pediatrics, Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10065, USA.
  • Elemento O; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Schwartz RE; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  • Buenrostro JD; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02142, USA.
  • Niec RE; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; The Rockefeller University, New York, NY 10065, USA.
Cell ; 186(18): 3882-3902.e24, 2023 08 31.
Article em En | MEDLINE | ID: mdl-37597510
ABSTRACT
Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. We found that circulating HSPC, enriched from peripheral blood, captured the diversity of bone marrow HSPC, enabling investigation of their epigenomic reprogramming following coronavirus disease 2019 (COVID-19). Alterations in innate immune phenotypes and epigenetic programs of HSPC persisted for months to 1 year following severe COVID-19 and were associated with distinct transcription factor (TF) activities, altered regulation of inflammatory programs, and durable increases in myelopoiesis. HSPC epigenomic alterations were conveyed, through differentiation, to progeny innate immune cells. Early activity of IL-6 contributed to these persistent phenotypes in human COVID-19 and a mouse coronavirus infection model. Epigenetic reprogramming of HSPC may underlie altered immune function following infection and be broadly relevant, especially for millions of COVID-19 survivors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Síndrome de COVID-19 Pós-Aguda / Memória Epigenética Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Síndrome de COVID-19 Pós-Aguda / Memória Epigenética Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos