Very early life microbiome and metabolome correlates with primary vaccination variability in children.
mSystems
; 8(5): e0066123, 2023 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-37610205
ABSTRACT
IMPORTANCE We show that simultaneous study of stool and nasopharyngeal microbiome reveals divergent timing and patterns of maturation, suggesting that local mucosal factors may influence microbiome composition in the gut and respiratory system. Antibiotic exposure in early life as occurs commonly, may have an adverse effect on vaccine responsiveness. Abundance of gut and/or nasopharyngeal bacteria with the machinery to produce lipopolysaccharide-a toll-like receptor 4 agonist-may positively affect future vaccine protection, potentially by acting as a natural adjuvant. The increased levels of serum phenylpyruvic acid in infants with lower vaccine-induced antibody levels suggest an increased abundance of hydrogen peroxide, leading to more oxidative stress in low vaccine-responding infants.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas
/
Microbiota
/
Microbioma Gastrointestinal
Limite:
Child
/
Humans
/
Infant
Idioma:
En
Revista:
MSystems
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos