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Dual-Responsive Drug-Delivery System Based on PEG-Functionalized Pillararenes Containing Disulfide and Amido Bonds for Cancer Theranostics.
Xia, Jiachen; Wang, Jian; Zhao, Qin; Lu, Bing; Yao, Yong.
Afiliação
  • Xia J; College of Chemistry and Chemical Engineering, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, 226019, P. R. China.
  • Wang J; College of Chemistry and Chemical Engineering, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, 226019, P. R. China.
  • Zhao Q; College of Chemistry and Chemical Engineering, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, 226019, P. R. China.
  • Lu B; College of Chemistry and Chemical Engineering, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, 226019, P. R. China.
  • Yao Y; College of Chemistry and Chemical Engineering, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, 226019, P. R. China.
Chembiochem ; 24(21): e202300513, 2023 11 02.
Article em En | MEDLINE | ID: mdl-37610867
ABSTRACT
The construction of a smart drug-delivery system based on amphiphilic pillararenes with multiple responsiveness properties has become an important way to improve the efficacy of tumor chemotherapy. Here, a new PEG-functionalized pillararene (EtP5-SS-PEG) containing disulfide and amido bonds was designed and synthesized, which has been used to construct a novel supramolecular nanocarrier through a host-guest interaction with a perylene diimide derivative (PDI-2NH4 ) and their supramolecular self-assembly. This nanocarrier showed good drug loading capability, and dual stimulus responsiveness to enzyme and GSH (glutathione). After loading of doxorubicin (DOX), the prepared nanodrugs displayed efficient DOX release and outstanding cancer theranostics ability.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicina de Precisão / Neoplasias Limite: Humans Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicina de Precisão / Neoplasias Limite: Humans Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article