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Apoptosis-related Prognostic Factors in Advanced Colorectal Cancer Determined Using Tissue Microarrays.
Ozaki, Kosuke; Sasaki, Kazuhito; Abe, Hiroyuki; Nozawa, Hiroaki; Murono, Koji; Emoto, Shigenobu; Ushiku, Tetsuo; Ishihara, Soichiro.
Afiliação
  • Ozaki K; Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan; kou.ozaki0122@gmail.com.
  • Sasaki K; Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Abe H; Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
  • Nozawa H; Department of Pathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
  • Murono K; Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
  • Emoto S; Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
  • Ushiku T; Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
  • Ishihara S; Department of Pathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Anticancer Res ; 43(9): 3935-3942, 2023 Sep.
Article em En | MEDLINE | ID: mdl-37648313
ABSTRACT
BACKGROUND/

AIM:

Cancer cells evade apoptosis in colorectal cancer (CRC); however, overlap between apoptosis and poor prognosis marker proteins in the invasive front of tumors has not been reported. Here, we aimed to clarify the relationship between apoptosis, apoptosis-related protein expression, and prognosis in the central and invasive front regions of CRC using tissue microarrays. PATIENTS AND

METHODS:

Data of 207 patients with pathological stage 3 CRC, who underwent radical surgery between October 2010 and November 2014, were retrospectively reviewed. We assessed apoptosis using M30 CytoDEATH, CD163, and p53 immunostaining in tumor sections in the center and invasive front using tissue microarrays and correlated the results with the survival outcomes.

RESULTS:

M30 CytoDEATH staining was negative; 134 cases (64.7%) were apoptosis-negative in the center and 103 (49.8%) were apoptosis-negative at the invasive front. CD163 positivity was observed in 16 cases (7.8%) in the center and in 36 cases (17.6%) at the invasive front; p53 positivity was observed in 33 (15.9%) and 64 (30.9%) cases in the center and invasive front, respectively. CD163 and p53 expression was not associated with survival outcomes; however, the apoptosis-negative group at the invasive front had significantly poorer survival outcomes (overall survival p=0.044, relapse-free survival p=0.001). We identified cases with a poor prognosis by combining apoptosis and CD163 expression.

CONCLUSION:

A lower apoptosis percentage at the invasive front is associated with a poorer prognosis. CRC cases with a poor prognosis can be identified by evaluating apoptosis and CD163 expression in the invasive front.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteína Supressora de Tumor p53 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Anticancer Res Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteína Supressora de Tumor p53 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Anticancer Res Ano de publicação: 2023 Tipo de documento: Article