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Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study.
Sanft, Tara; Harrigan, Maura; McGowan, Courtney; Cartmel, Brenda; Zupa, Michelle; Li, Fang-Yong; Ferrucci, Leah M; Puklin, Leah; Cao, Anlan; Nguyen, Thai Hien; Neuhouser, Marian L; Hershman, Dawn L; Basen-Engquist, Karen; Jones, Beth A; Knobf, Tish; Chagpar, Anees B; Silber, Andrea; Tanasijevic, Anna; Ligibel, Jennifer A; Irwin, Melinda L.
Afiliação
  • Sanft T; Yale University School of Medicine, New Haven, CT.
  • Harrigan M; Yale Cancer Center, New Haven, CT.
  • McGowan C; Yale School of Public Health, New Haven, CT.
  • Cartmel B; Yale School of Public Health, New Haven, CT.
  • Zupa M; Yale Cancer Center, New Haven, CT.
  • Li FY; Yale School of Public Health, New Haven, CT.
  • Ferrucci LM; Yale School of Public Health, New Haven, CT.
  • Puklin L; Yale School of Public Health, New Haven, CT.
  • Cao A; Yale Cancer Center, New Haven, CT.
  • Nguyen TH; Yale School of Public Health, New Haven, CT.
  • Neuhouser ML; Yale School of Public Health, New Haven, CT.
  • Hershman DL; Yale School of Public Health, New Haven, CT.
  • Basen-Engquist K; Yale School of Public Health, New Haven, CT.
  • Jones BA; Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Knobf T; Columbia University Medical Center, New York, NY.
  • Chagpar AB; The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Silber A; Yale Cancer Center, New Haven, CT.
  • Tanasijevic A; Yale School of Public Health, New Haven, CT.
  • Ligibel JA; Yale Cancer Center, New Haven, CT.
  • Irwin ML; Yale School of Nursing, New Haven, CT.
J Clin Oncol ; 41(34): 5285-5295, 2023 Dec 01.
Article em En | MEDLINE | ID: mdl-37656930
PURPOSE: Successful completion of chemotherapy is critical to improve breast cancer outcomes. Relative dose intensity (RDI), defined as the ratio of chemotherapy delivered to prescribed, is a measure of chemotherapy completion and is associated with cancer mortality. The effect of exercise and eating a healthy diet on RDI is unknown. We conducted a randomized trial of an exercise and nutrition intervention on RDI and pathologic complete response (pCR) in women diagnosed with breast cancer initiating chemotherapy. METHODS: One hundred seventy-three women with stage I-III breast cancer were randomly assigned to usual care (UC; n = 86) or a home-based exercise and nutrition intervention with counseling sessions delivered by oncology-certified registered dietitians (n = 87). Chemotherapy dose adjustments and delays and pCR were abstracted from electronic medical records. T-tests and chi-square tests were used to examine the effect of the intervention versus UC on RDI and pCR. RESULTS: Participants randomly assigned to intervention had greater improvements in exercise and diet quality compared with UC (P < .05). RDI was 92.9% ± 12.1% and 93.6% ± 11.1% for intervention and UC, respectively (P = .69); the proportion of patients in the intervention versus UC who achieved ≥85% RDI was 81% and 85%, respectively (P = .44). The proportion of patients who had at least one dose reduction and/or delay was 38% intervention and 36% UC (P = .80). Among 72 women who received neoadjuvant chemotherapy, women randomly assigned to intervention were more likely to have a pCR than those randomly assigned to UC (53% v 28%; P = .037). CONCLUSION: Although a diet and exercise intervention did not affect RDI, the intervention was associated with a higher pCR in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative and triple-negative breast cancer undergoing neoadjuvant chemotherapy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias de Mama Triplo Negativas Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Female / Humans Idioma: En Revista: J Clin Oncol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias de Mama Triplo Negativas Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Female / Humans Idioma: En Revista: J Clin Oncol Ano de publicação: 2023 Tipo de documento: Article