Comprehensive geriatric assessment predicts radiation-induced acute toxicity in prostate cancer patients.
Strahlenther Onkol
; 200(3): 208-218, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-37658924
ABSTRACT
PURPOSE:
The purpose of the present prospective study was to evaluate the significance of geriatric conditions measured by a comprehensive geriatric assessment (GA) for the prediction of the risk of high-grade acute radiation-induced toxicity.METHODS:
A total of 314 prostate cancer patients (age ≥â¯65 years) undergoing definitive radiotherapy at a tertiary academic center were included. Prior to treatment, patients underwent a GA. High-grade toxicity was defined as acute toxicity grade ≥â¯2 according to standard RTOG/EORTC criteria. To analyze the predictive value of the GA, univariable and multivariable logistic regression models were applied.RESULTS:
A total of 40 patients (12.7%) developed acute toxicity grade ≥â¯2; high grade genitourinary was found in 37 patients (11.8%) and rectal toxicity in 8 patients (2.5%), respectively. Multivariable analysis revealed a significant association of comorbidities with overall toxicity grade ≥â¯2 (odds ratio [OR] 2.633, 95% confidence interval [CI] 1.260-5.502; pâ¯= 0.010) as well as with high-grade genitourinary and rectal toxicity (OR 2.169, 95%CI1.017-4.625; pâ¯= 0.045 and OR 7.220, 95%CI 1.227-42.473; pâ¯= 0.029, respectively). Furthermore, the Activities of Daily Living score (OR 0.054, 95%CI 0.004-0.651; pâ¯= 0.022), social status (OR 0.159, 95%CI 0.028-0.891; pâ¯= 0.036), and polypharmacy (OR 4.618, 95%CI 1.045-20.405; pâ¯= 0.044) were identified as independent predictors of rectal toxicity grade ≥â¯2.CONCLUSION:
Geriatric conditions seem to be predictive of the development of high-grade radiation-induced toxicity in prostate cancer patients treated with definitive radiotherapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Lesões por Radiação
/
Radioterapia Conformacional
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Strahlenther Onkol
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Áustria