Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.

Li, Min; Wei, Jun; Zhu, Guofeng; Fu, Shufang; He, Xiaoyan; Hu, Xinqian; Yu, Yajie; Mou, Yan; Wang, Jia; You, Xiaoling; Xiao, Xin; Gu, Tanrong; Ye, Zhi; Zha, Yunhong

Li, Min; Wei, Jun; Zhu, Guofeng; Fu, Shufang; He, Xiaoyan; Hu, Xinqian; Yu, Yajie; Mou, Yan; Wang, Jia; You, Xiaoling; Xiao, Xin; Gu, Tanrong; Ye, Zhi; Zha, Yunhong.

Afiliação

Li M; Institute of Neural Regeneration and Repair, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Wei J; Department of Neurology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Zhu G; Yichang Central People's Hospital, Yichang, China.
Fu S; Institute of Neural Regeneration and Repair, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
He X; Department of Neurology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Hu X; Yichang Central People's Hospital, Yichang, China.
Yu Y; Institute of Neural Regeneration and Repair, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Mou Y; Department of Neurology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Wang J; Yichang Central People's Hospital, Yichang, China.
You X; Yichang Central People's Hospital, Yichang, China.
Xiao X; Department of Paediatrics, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Gu T; Institute of Neural Regeneration and Repair, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Ye Z; Department of Neurology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Zha Y; Yichang Central People's Hospital, Yichang, China.

FASEB J ; 37(10): e23178, 2023 10.

Article em En | MEDLINE | ID: mdl-37698367

Assuntos

Necroptose; Proteína Serina-Treonina Quinases de Interação com Receptores; Fator de Necrose Tumoral alfa; Animais; Camundongos; Serina; Treonina

Palavras-chave

necroptosis; quizartinib; receptor-interacting serine/threonine protein kinase 1; repurposing; systemic inflammatory response syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Proteína Serina-Treonina Quinases de Interação com Receptores / Necroptose Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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