Ketamine: Mechanisms and Relevance to Treatment of Depression.
Annu Rev Med
; 75: 129-143, 2024 Jan 29.
Article
em En
| MEDLINE
| ID: mdl-37729028
ABSTRACT
Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patients highlight the need for improved therapeutic approaches. Over the past two decades, ketamine has shown rapid onset with sustained (up to several days) antidepressant effects in patients whose MDD has not responded to conventional antidepressant drugs. Recent preclinical studies have started to elucidate the underlying mechanisms of ketamine's antidepressant properties. Herein, we describe and compare recent clinical and preclinical findings to provide a broad perspective of the relevant mechanisms for the antidepressant action of ketamine.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Depressivo Maior
/
Ketamina
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Med
Ano de publicação:
2024
Tipo de documento:
Article