Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis.
J Integr Neurosci
; 22(5): 115, 2023 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-37735121
ABSTRACT
BACKGROUND:
Many studies have shown that the levels of homocysteine (Hcy), vitamin B12 (Vit B12), and folate (FA) are abnormal in patients with Parkinson's disease (PD), but the results have not been consistent. Therefore, we conducted this meta-analysis to summarize the features of Hcy, Vit B12, and FA in PD patients.METHODS:
A systematic literature search was conducted on PubMed, Cochrane Library, Web of Science, and Embase databases.RESULTS:
A total of 71 studies were included. The analysis showed the following. (1) PD patients had significantly increased Hcy level (standardized mean difference [SMD] 0.80, 95% confidence interval [CI] [0.61, 0.99]; p < 0.001), and decreased Vit B12 (SMD -0.33, 95% CI [-0.43, -0.22]; p <0.001) and FA levels (SMD -0.13, 95% CI [-0.19, -0.06]; p < 0.001) compared to healthy controls. (2) Higher Hcy level (SMD 0.48, 95% CI [0.30, 0.67]; p < 0.001) was found in Dopaminergic medications treated PD patients than in untreated patients. (3) PD patients with cognitive impairment had higher Hcy level (SMD 0.71, 95% CI [0.50, 0.92]; p < 0.001) and lower Vit B12 (SMD -0.22, 95% CI [-0.34, -0.09]; p = 0.001) and FA levels (SMD -0.17, 95% CI [-0.29, -0.04]; p = 0.009) than those with no cognitive impairment. (4) PD patients with neuropathy had significantly increased Hcy level (SMD 0.87, 95% CI [0.43, 1.31]; p < 0.001) and decreased Vit B12 level (SMD -0.40, 95% CI [-0.81, -0.00]; p = 0.049) compared to PD patients with no neuropathy.CONCLUSIONS:
In conclusion, PD patients may have higher Hcy levels and lower Vit B12 and FA levels than the healthy population. Thus, Hcy, Vit B12, and FA may play a role in cognitive impairment and neuropathy in PD patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Disfunção Cognitiva
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Integr Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China