ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization.

Lu, Xiaolin; Liu, Ruiqi; Liao, Yuanyu; Cui, Luying; Sun, Haoxiu; Zhang, Dongzhi; Wang, Bojun; Fang, Lin; Guan, Xin; Yao, Yuanfei; Liu, Chao; Zhang, Yanqiao

Lu, Xiaolin; Liu, Ruiqi; Liao, Yuanyu; Cui, Luying; Sun, Haoxiu; Zhang, Dongzhi; Wang, Bojun; Fang, Lin; Guan, Xin; Yao, Yuanfei; Liu, Chao; Zhang, Yanqiao.

Afiliação

Lu X; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Liu R; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.
Liao Y; China Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.
Cui L; Department of Orthopedic Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Sun H; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhang D; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Wang B; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Fang L; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Guan X; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, China.
Yao Y; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Liu C; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Zhang Y; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

BMC Med ; 21(1): 366, 2023 09 25.

Article em En | MEDLINE | ID: mdl-37743483

Assuntos

Neoplasias Colorretais; MicroRNAs; Humanos; beta Catenina/genética; beta Catenina/metabolismo; beta Catenina/farmacologia; Lisina/genética; Lisina/metabolismo; Lisina/farmacologia; MicroRNAs/metabolismo; Glutationa Peroxidase/genética; Glutationa Peroxidase/metabolismo; Glutationa Peroxidase/farmacologia; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/genética; Regulação Neoplásica da Expressão Gênica; Receptores de Activinas Tipo II/genética; Receptores de Activinas Tipo II/metabolismo; Receptores de Activinas Tipo II/farmacologia; Proteases Específicas de Ubiquitina/genética; Proteases Específicas de Ubiquitina/metabolismo; Proteases Específicas de Ubiquitina/farmacologia

Palavras-chave

Activin A receptor-like type 1; Colorectal cancer; Drug resistance; Glutathione peroxidase 2; Multitarget tyrosine kinase inhibitors; Reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / MicroRNAs Limite: Humans Idioma: En Revista: BMC Med Assunto da revista: MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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