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Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription.
Cameron, Donald P; Grosser, Jan; Ladigan, Swetlana; Kuzin, Vladislav; Iliopoulou, Evanthia; Wiegard, Anika; Benredjem, Hajar; Jackson, Kathryn; Liffers, Sven T; Lueong, Smiths; Cheung, Phyllis F; Vangala, Deepak; Pohl, Michael; Viebahn, Richard; Teschendorf, Christian; Wolters, Heiner; Usta, Selami; Geng, Keyi; Kutter, Claudia; Arsenian-Henriksson, Marie; Siveke, Jens T; Tannapfel, Andrea; Schmiegel, Wolff; Hahn, Stephan A; Baranello, Laura.
Afiliação
  • Cameron DP; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Grosser J; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Ladigan S; Ruhr University Bochum, Faculty of Medicine, Department of Molecular GI Oncology, Bochum, Germany.
  • Kuzin V; Ruhr University Bochum, Knappschaftskrankenhaus, Department of Internal Medicine, Bochum, Germany.
  • Iliopoulou E; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Wiegard A; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Benredjem H; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Jackson K; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Liffers ST; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Lueong S; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.
  • Cheung PF; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Vangala D; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.
  • Pohl M; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Viebahn R; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.
  • Teschendorf C; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Wolters H; Ruhr University Bochum, Faculty of Medicine, Department of Molecular GI Oncology, Bochum, Germany.
  • Usta S; Ruhr University Bochum, Knappschaftskrankenhaus, Department of Internal Medicine, Bochum, Germany.
  • Geng K; Ruhr University Bochum, Knappschaftskrankenhaus, Department of Internal Medicine, Bochum, Germany.
  • Kutter C; Ruhr University Bochum, Knappschaftskrankenhaus, Department of Surgery, Bochum, Germany.
  • Arsenian-Henriksson M; Department of Internal Medicine, St. Josef-Hospital, Dortmund, Germany.
  • Siveke JT; Department of Visceral and General Surgery, St. Josef-Hospital, Dortmund, Germany.
  • Tannapfel A; Department of Visceral and General Surgery, St. Josef-Hospital, Dortmund, Germany.
  • Schmiegel W; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Hahn SA; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
  • Baranello L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Sci Adv ; 9(41): eadg5109, 2023 10 13.
Article em En | MEDLINE | ID: mdl-37831776
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Fatores de Transcrição Limite: Humans Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Fatores de Transcrição Limite: Humans Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia