Confluence and convergence of Dscam and Pcdh cell-recognition codes.
Trends Biochem Sci
; 48(12): 1044-1057, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37839971
ABSTRACT
The ability of neurites of the same neuron to avoid each other (self-avoidance) is a conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the generation of a unique subset of cell-surface proteins in individual neurons engaging in isoform-specific homophilic interactions that drive neurite repulsion rather than adhesion. Among these cell-surface proteins are fly Dscam1 and vertebrate clustered protocadherins (cPcdhs), as well as the recently characterized shortened Dscam (sDscam) in the Chelicerata. Herein, we review recent advances in our understanding of how cPcdh, Dscam, and sDscam cell-surface recognition codes are expressed and translated into cellular functions essential for neural wiring.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular
/
Proteínas de Drosophila
/
Protocaderinas
Limite:
Animals
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China