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Mechanistic interplay of different mediators involved in mediating the anti-depressant effect of isoflavones.
Singh, Lovedeep; Bhatia, Deepika.
Afiliação
  • Diksha; University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India.
  • Singh L; University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India. lovedeep.e13279@cumail.in.
  • Bhatia D; University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India.
Metab Brain Dis ; 39(1): 199-215, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37855935
Depression is one of the most prevalent severe CNS disorders, which negatively affects social lives, the ability to work, and the health of people. As per the World Health Organisation (WHO), it is a psychological disorder that is estimated to be a leading disease by 2030. Clinically, various medicines have been formulated to treat depression but they are having a setback due to their side effects, slow action, or poor bioavailability. Nowadays, flavonoids are regarded as an essential component in a variety of nutraceutical, pharmaceutical and medicinal. Isoflavones are a distinctive and important subclass of flavonoids that are generally obtained from soybean, chickpeas, and red clover. The molecules of this class have been extensively explored in various CNS disorders including depression and anxiety. Isoflavones such as genistein, daidzein, biochanin-A, formononetin, and glycitein have been reported to exert an anti-depressant effect through the modulation of different mediators. Fatty acid amide hydrolase (FAAH) mediated depletion of anandamide and hypothalamic-pituitary-adrenal (HPA) axis-mediated modulation of brain-derived neurotrophic factor (BDNF), monoamine oxidase (MAO) mediated depletion of biogenic amines and inflammatory signaling are the important underlying pathways leading to depression. Upregulation in the levels of BDNF, anandamide, antioxidants and monoamines, along with inhibition of MAO, FAAH, HPA axis, and inflammatory stress are the major modulations produced by different isoflavones in the observed anti-depressant effect. Therefore, the present review has been designed to explore the mechanistic interplay of various mediators involved in mediating the anti-depressant action of different isoflavones.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Araquidônicos / Fator Neurotrófico Derivado do Encéfalo / Endocanabinoides / Alcamidas Poli-Insaturadas / Isoflavonas Limite: Humans Idioma: En Revista: Metab Brain Dis Assunto da revista: CEREBRO / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Araquidônicos / Fator Neurotrófico Derivado do Encéfalo / Endocanabinoides / Alcamidas Poli-Insaturadas / Isoflavonas Limite: Humans Idioma: En Revista: Metab Brain Dis Assunto da revista: CEREBRO / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia