Delayed isotype switching in Dirofilaria immitis infection.
Trans R Soc Trop Med Hyg
; 80(2): 305-8, 1986.
Article
em En
| MEDLINE
| ID: mdl-3787691
ABSTRACT
The anti-microfilarial immunoglobulin response in Dirofilaria immitis infection was investigated serially in a naturally infected dog. Spontaneous clearance of microfilariae was associated with IgM opsonizing antibodies which promoted in vitro killing of microfilariae by granulocytes. Over a 6- to 11-month period, there was a shift to a predominantly IgG response. The addition of fresh non-immune serum markedly enhanced killing mediated by both IgM and IgG. The findings document conversion from IgM to IgG isotype with chronic infection, and suggest that isotype switching in canine D. immitis infection is delayed relative to that seen in bacterial or viral infections.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isotipos de Imunoglobulinas
/
Dirofilariose
Limite:
Animals
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
1986
Tipo de documento:
Article