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Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer.
Li, Peng; Zhen, Yuanli; Kim, Chiho; Liu, Zhengshuai; Hao, Jianwei; Deng, Heping; Deng, Hejun; Zhou, Min; Wang, Xu-Dong; Qin, Tian; Yu, Yonghao.
Afiliação
  • Li P; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Zhen Y; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Kim C; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Liu Z; Department of Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
  • Hao J; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Deng H; Department of Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
  • Deng H; Department of Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
  • Zhou M; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang XD; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Qin T; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Yu Y; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sci Adv ; 9(43): eadg7752, 2023 10 27.
Article em En | MEDLINE | ID: mdl-37878693
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutações Sintéticas Letais / Neoplasias Limite: Humans Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutações Sintéticas Letais / Neoplasias Limite: Humans Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos