Nickel-Catalyzed Acid Chlorides with Tetrasulfides for the Synthesis of Thioesters and Acyl Disulfides.

Chen, Wang; Sheng, Daopeng; Jiang, Yi-Fan; Zhu, Wei-Chen; Rao, Weidong; Shen, Shu-Su; Yang, Zhao-Ying; Wang, Shun-Yi

Chen, Wang; Sheng, Daopeng; Jiang, Yi-Fan; Zhu, Wei-Chen; Rao, Weidong; Shen, Shu-Su; Yang, Zhao-Ying; Wang, Shun-Yi.

Afiliação

Chen W; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China.
Sheng D; Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Jiang YF; State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.
Zhu WC; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China.
Rao W; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China.
Shen SS; Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Yang ZY; School of Environmental Science and Engineering, Suzhou University of Science and Technology, No. 99, Xuefu Road, Huqiu District, Suzhou, 215009, PR China.
Wang SY; Soochow College, Soochow University, Suzhou, 215123, China.

J Org Chem ; 88(22): 15871-15880, 2023 Nov 17.

Article em En | MEDLINE | ID: mdl-37882877

ABSTRACT

ABSTRACT

Herein, we report a novel method for the synthesis of thioesters and acyl disulfides via nickel-catalyzed reductive cross-electrophile coupling of acid chlorides with tetrasulfides. This approach for the synthesis of thioesters and acyl disulfides is convenient and practical under mild reaction conditions, relying on easy availability. In addition, a wide range of thioesters and acyl disulfides were obtained in medium to good yields with good functional group tolerance. Moreover, thioesters and acyl disulfides can also be prepared at the gram scale, indicating that they have certain potential for industrial application.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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