Deubiquitinase OTUD5 promotes hepatitis B virus replication by removing K48-linked ubiquitination of HBV core/precore and upregulates HNF4É expressions by inhibiting the ERK1/2/mitogen-activated protein kinase pathway.

Lou, Bin; Ma, Guanghua; Yu, Xiaopeng; Lv, Feifei; Xu, Fanjie; Sun, Chengdi; Chen, Yu

Deubiquitinase OTUD5 promotes hepatitis B virus replication by removing K48-linked ubiquitination of HBV core/precore and upregulates HNF4É expressions by inhibiting the ERK1/2/mitogen-activated protein kinase pathway.

Lou, Bin; Ma, Guanghua; Yu, Xiaopeng; Lv, Feifei; Xu, Fanjie; Sun, Chengdi; Chen, Yu.

Afiliação

Lou B; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road, Hangzhou, 310003, China.
Ma G; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, 310003, China.
Yu X; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, 310003, China.
Lv F; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road, Hangzhou, 310003, China.
Xu F; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, China.
Sun C; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road, Hangzhou, 310003, China.
Chen Y; The Shengzhou Hospital of Traditional Chinese Medicine, Shaoxing, 312432, Zhejiang, China.

Cell Mol Life Sci ; 80(11): 336, 2023 Oct 28.

Article em En | MEDLINE | ID: mdl-37897511

Assuntos

Vírus da Hepatite B; Hepatite B; Humanos; Sistema de Sinalização das MAP Quinases; Proteínas Quinases Ativadas por Mitógeno; Células Hep G2; Ubiquitinação; Replicação Viral; Enzimas Desubiquitinantes/genética

Palavras-chave

Deubiquitinase; HBV; HBV core/precore protein; HNF4É; MAPK signal pathway; OTUD5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Hepatite B Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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