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Vaccine-induced antibody Fc-effector functions in humans immunized with a combination Ad26.RSV.preF/RSV preF protein vaccine.
Bartsch, Yannic C; Cizmeci, Deniz; Yuan, Dansu; Mehta, Nickita; Tolboom, Jeroen; De Paepe, Els; van Heesbeen, Roy; Sadoff, Jerald; Comeaux, Christy A; Heijnen, Esther; Callendret, Benoit; Alter, Galit; Bastian, Arangassery Rosemary.
Afiliação
  • Bartsch YC; Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
  • Cizmeci D; Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
  • Yuan D; Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts, USA.
  • Mehta N; Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
  • Tolboom J; Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
  • De Paepe E; Janssen Vaccines & Prevention B.V. , Leiden, South Holland, the Netherlands.
  • van Heesbeen R; Janssen Infectious Diseases , Beerse, Belgium.
  • Sadoff J; Janssen Vaccines & Prevention B.V. , Leiden, South Holland, the Netherlands.
  • Comeaux CA; Janssen Vaccines & Prevention B.V. , Leiden, South Holland, the Netherlands.
  • Heijnen E; Janssen Vaccines & Prevention B.V. , Leiden, South Holland, the Netherlands.
  • Callendret B; Janssen Vaccines & Prevention B.V. , Leiden, South Holland, the Netherlands.
  • Alter G; Janssen Vaccines & Prevention B.V. , Leiden, South Holland, the Netherlands.
  • Bastian AR; Ragon Institute of MGH, MIT, and Harvard , Cambridge, Massachusetts, USA.
J Virol ; 97(11): e0077123, 2023 Nov 30.
Article em En | MEDLINE | ID: mdl-37902399
ABSTRACT
IMPORTANCE Respiratory syncytial virus (RSV) can cause serious illness in older adults (i.e., those aged ≥60 years). Because options for RSV prophylaxis and treatment are limited, the prevention of RSV-mediated illness in older adults remains an important unmet medical need. Data from prior studies suggest that Fc-effector functions are important for protection against RSV infection. In this work, we show that the investigational Ad26.RSV.preF/RSV preF protein vaccine induced Fc-effector functional immune responses in adults aged ≥60 years who were enrolled in a phase 1/2a regimen selection study of Ad26.RSV.preF/RSV preF protein. These results demonstrate the breadth of the immune responses induced by the Ad26.RSV.preF/RSV preF protein vaccine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus Respiratório Sincicial / Vacinas contra Vírus Sincicial Respiratório Limite: Aged / Humans Idioma: En Revista: J Virol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus Respiratório Sincicial / Vacinas contra Vírus Sincicial Respiratório Limite: Aged / Humans Idioma: En Revista: J Virol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos