Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study.
PLoS One
; 18(11): e0293883, 2023.
Article
em En
| MEDLINE
| ID: mdl-37917761
ABSTRACT
BACKGROUND:
To mitigate mortality among critically ill COVID-19 patients, both during their Intensive Care Unit (ICU) stay and following ICU discharge, it is crucial to measure its frequency, identify predictors and to establish an appropriate post-ICU follow-up strategy.METHODS:
In this multicentre, prospective cohort study, we included 586 critically ill COVID-19 patients.RESULTS:
We observed an overall ICU mortality of 20.1% [95%CI 17.1% to 23.6%] (118/586) and an overall hospital mortality of 25.4% [95%CI 22.1% to 29.1%] (149/586). For ICU survivors, 30 days (early) post-ICU mortality was 5.3% [95%CI 3.6% to 7.8%] (25/468) and one-year (late) post-ICU mortality was 7.9% [95%CI 5.8% to 10.8%] (37/468). Pre-existing conditions/comorbidities were identified as the main independent predictors of mortality after ICU discharge hypertension and heart failure were independent predictors of early mortality; and hypertension, chronic kidney disease, chronic obstructive pulmonary disease and cancer were independent predictors of late mortality.CONCLUSION:
Early and late post-ICU mortality exhibited an initial surge (in the first 30 days post-ICU) followed by a subsequent decline over time. Close monitoring of critically ill COVID-19 post-ICU survivors, especially those with pre-existing conditions, is crucial to prevent adverse outcomes, reduce mortality and to establish an appropriate follow-up strategy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
COVID-19
/
Hipertensão
Limite:
Humans
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Portugal