Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling.

Javed, Sehrish; Chang, Ya-Ting; Cho, Yoobin; Lee, Yu-Ju; Chang, Hao-Cheng; Haque, Minza; Lin, Yu Cheng; Huang, Wei-Hsiang

Javed, Sehrish; Chang, Ya-Ting; Cho, Yoobin; Lee, Yu-Ju; Chang, Hao-Cheng; Haque, Minza; Lin, Yu Cheng; Huang, Wei-Hsiang.

Afiliação

Javed S; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Canada.
Chang YT; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Canada.
Cho Y; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Canada.
Lee YJ; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Canada.
Chang HC; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Canada.
Haque M; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Canada.
Lin YC; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Canada.
Huang WH; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Canada.

Elife ; 122023 11 13.

Article em En | MEDLINE | ID: mdl-37956053

Assuntos

Fator Neurotrófico Derivado do Encéfalo; Síndrome de Smith-Magenis; Transativadores; Fatores de Transcrição; Animais; Camundongos; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Homeostase; Hipotálamo/metabolismo; Neurônios/metabolismo; Obesidade/genética; Síndrome de Smith-Magenis/genética; Síndrome de Smith-Magenis/metabolismo; Transativadores/metabolismo; Fatores de Transcrição/metabolismo; Fatores de Crescimento Neural/metabolismo; Peso Corporal

Palavras-chave

brain-derived neurotrophic factor; mouse; neuroscience; obesity; paraventricular nucleus of hypothalamus; retinoic acid induced 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Transativadores / Fator Neurotrófico Derivado do Encéfalo / Síndrome de Smith-Magenis Limite: Animals Idioma: En Revista: Elife Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

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