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Efficacy of highly purified cannabidiol (CBD) in typical absence seizures: A pilot study.
Azevedo, Marina; Benbadis, Selim R.
Afiliação
  • Azevedo M; Comprehensive Epilepsy Center, University of South Florida, Tampa, FL 33606, United States. Electronic address: azevedom@usf.edu.
  • Benbadis SR; Comprehensive Epilepsy Center, University of South Florida, Tampa, FL 33606, United States. Electronic address: sbenbadi@usf.edu.
Epilepsy Behav ; 149: 109512, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37980860
OBJECTIVES: Clinical trials for typical absence seizures are notoriously difficult, because those seizures are clinically subtle and brief, so that seizure counts by caregivers are inaccurate. As a result, treatment options are limited. Currently, there are no published studies on the use of CBD in typical absence seizures. This pilot study aims to evaluate the efficacy of pharmaceutical grade CBD in typical absence seizures. METHODS: We prospectively enrolled 14 patients aged 6 years and older, diagnosed with typical absence seizures. A baseline 24-hour ambulatory EEG was conducted, followed by a second 24-hour EEG after 90 days of treatment. The outcome was an objective measure of spike-wave complexes (SWC) burden change from pre- to post- treatment. RESULTS: After taking CBD for 90 days, 9 (64.3%) patients had an increase in SWC (ranging from 8% to 2876.5%) and 5 (35.7%) had a decrease in SWC (ranging from 62.3% to 98.9%). Of the 5 patients who had a decrease, 3 (60%) were on concomitant ethosuximide (with or without other ASMs). All 3 patients on CBD and ethosuximide improved. CONCLUSIONS: Although based on a small subset of patients, our results suggest that CBD may not be effective for typical absence seizures. However, patients on concomitant ethosuximide or on CBD monotherapy were more likely to improve.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabidiol Limite: Humans Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabidiol Limite: Humans Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article