Real-world outcomes with fedratinib therapy in patients who discontinued ruxolitinib for primary myelofibrosis.
Future Oncol
; 2023 Nov 22.
Article
em En
| MEDLINE
| ID: mdl-37991002
ABSTRACT
Aim:
Fedratinib is an oral selective JAK2 inhibitor approved in the USA for the treatment of adult patients with intermediate-2 or high-risk primary or secondary myelofibrosis (MF).Methods:
This observational study assessed adult US patients who received ruxolitinib for primary MF (Flatiron Health database 1 January 2011-31 October 2020). Patients were stratified by post-ruxolitinib treatment (fedratinib vs non-fedratinib).Results:
Characteristics were comparable between fedratinib (n=70) and non-fedratinib (n=159) groups (median age 71.0 vs 70.0 years; females 55.7 vs 50.3%; median follow-up 7.0 vs 6.0 months). Median overall survival (not reached vs 17 months) and 12 month survival (71.6 vs 53.5%) were improved with fedratinib versus the non-fedratinib therapies.Conclusion:
In MF patients who received frontline ruxolitinib, survival was improved with subsequent fedratinib versus non-fedratinib care.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália