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Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
Thoma, Gebhard; Markert, Christian; Lueoend, Rainer; Miltz, Wolfgang; Spanka, Carsten; Bollbuck, Birgit; Wolf, Romain M; Srinivas, Honnappa; Penno, Carlos A; Kiffe, Michael; Gajewska, Monika; Bednarczyk, Dallas; Wieczorek, Grazyna; Evans, Amanda; Beerli, Christian; Röhn, Till A.
Afiliação
  • Thoma G; Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Markert C; Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Lueoend R; Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Miltz W; Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Spanka C; Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Bollbuck B; Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Wolf RM; Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Srinivas H; Chemical Biology & Therapeutics, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Penno CA; Chemical Biology & Therapeutics, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Kiffe M; PK Sciences, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Gajewska M; PK Sciences, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Bednarczyk D; Discovery & Translational Lab, Biomedical Research, Novartis Pharma AG, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Wieczorek G; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Evans A; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Beerli C; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
  • Röhn TA; Immunology Disease Area, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.
J Med Chem ; 66(23): 16410-16425, 2023 12 14.
Article em En | MEDLINE | ID: mdl-38015154
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epóxido Hidrolases / Fígado Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epóxido Hidrolases / Fígado Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça