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HPV-negative head and neck cancers with adverse pathological features carry specific molecular changes that are associated with survival.
Kim, Hugh Andrew Jinwook; Zeng, Peter Y F; Cecchini, Matthew; Shaikh, Mushfiq Hassan; Laxague, Francisco; Deng, Xiaoxiao; Jarycki, Laura; Ryan, Sarah Elizabeth Belle; Dawson, Alice; Liu, Mu Han; Palma, David A; Patel, Krupal; Mundi, Neil; Barrett, John W; Mymryk, Joe S; Boutros, Paul C; Nichols, Anthony C.
Afiliação
  • Kim HAJ; Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Zeng PYF; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Cecchini M; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.
  • Shaikh MH; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Laxague F; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Deng X; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Jarycki L; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Ryan SEB; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Dawson A; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.
  • Liu MH; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Palma DA; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.
  • Patel K; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Mundi N; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
  • Barrett JW; Department of Oncology, University of Western Ontario, London, Ontario, Canada.
  • Mymryk JS; Department of Otolaryngology-Head & Neck Surgery, Moffitt Cancer Center, Tampa, Florida, USA.
  • Boutros PC; Department of Otolaryngology-Head & Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
  • Nichols AC; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Head Neck ; 46(2): 353-366, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38059331
ABSTRACT

BACKGROUND:

Adverse pathological features following surgery in head and neck squamous cell carcinoma (HNSCC) are strongly associated with survival and guide adjuvant therapy. We investigated molecular changes associated with these features.

METHODS:

We downloaded data from the Cancer Genome Atlas and Cancer Proteome Atlas HNSCC cohorts. We compared tumors positive versus negative for perineural invasion (PNI), lymphovascular invasion (LVI), extracapsular spread (ECS), and positive margins (PSM), with multivariable analysis.

RESULTS:

All pathological features were associated with poor survival, as were the following molecular changes low cyclin E1 (HR = 1.7) and high PKC-alpha (HR = 1.8) in tumors with PNI; six of 13 protein abundance changes with LVI; greater tumor hypoxia and high Raptor (HR = 2.0) and Rictor (HR = 1.6) with ECS; and low p38 (HR = 2.3), high fibronectin (HR = 1.6), low annexin A1 (HR = 3.1), and high caspase-9 (HR = 1.6) abundances with PSM.

CONCLUSIONS:

Pathological features in HNSCC carry specific molecular changes that may explain their poor prognostic associations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Papillomavirus / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Papillomavirus / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá