Toward a CRISPR understanding of gene function in human brain development.

Li, Emmy; Kampmann, Martin

Li, Emmy; Kampmann, Martin.

Afiliação

Li E; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. Electronic address: emmy.li@ucsf.edu.
Kampmann M; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: martin.kampmann@ucsf.edu.

Cell Stem Cell ; 30(12): 1561-1562, 2023 12 07.

Article em En | MEDLINE | ID: mdl-38065064

RESUMO

Genome-wide association studies pinpoint genetic risk factors for neurodevelopmental disorders (NDDs), but the next challenge is to understand the mechanisms through which these genes affect brain development. Two recent CRISPR screens in human brain organoids1,2 interrogate the function of risk genes for autism spectrum disorder and other NDDs.

Assuntos

Transtorno do Espectro Autista; Transtornos do Neurodesenvolvimento; Humanos; Transtorno do Espectro Autista/genética; Estudo de Associação Genômica Ampla; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas/genética; Encéfalo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Neurodesenvolvimento / Transtorno do Espectro Autista Limite: Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2023 Tipo de documento: Article

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