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Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents-In Vitro Evaluation against Breast Cancer Cells.
Guillén-Mancina, Emilio; García-Lozano, María Del Rosario; Burgos-Morón, Estefanía; Mazzotta, Sarah; Martínez-Aguado, Pablo; Calderón-Montaño, José Manuel; Vega-Pérez, José Manuel; López-Lázaro, Miguel; Iglesias-Guerra, Fernando; Vega-Holm, Margarita.
Afiliação
  • Guillén-Mancina E; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • García-Lozano MDR; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Burgos-Morón E; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, 41013 Seville, Spain.
  • Mazzotta S; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Martínez-Aguado P; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Calderón-Montaño JM; Department of Chemistry, University of Milan, 20133 Milan, Italy.
  • Vega-Pérez JM; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • López-Lázaro M; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, 41013 Seville, Spain.
  • Iglesias-Guerra F; Infectious Diseases and Microbiology Clinical Unit, University Hospital Virgen Macarena, 41009 Seville, Spain.
  • Vega-Holm M; Departament of Medicine, School of Medicine, University of Seville, 41012 Seville, Spain.
Int J Mol Sci ; 24(23)2023 Dec 01.
Article em En | MEDLINE | ID: mdl-38069364
Breast cancer is the most common type of cancer in women. Although current treatments can increase patient survival, they are rarely curative when the disease is advanced (metastasis). Therefore, there is an urgent need to develop new cytotoxic drugs with a high selectivity toward cancer cells. Since repurposing approved drugs for cancer therapy has been a successful strategy in recent years, in this study, we screened a library of antiviral piperazine-derived compounds as anticancer agents. The compounds included a piperazine ring and aryl urea functions, which are privileged structures present in several anti-breast cancer drugs. The selective cytotoxic activity of a set of thirty-four 4-acyl-2-substituted piperazine urea derivatives against MCF7 breast cancer cells and MCF 10A normal breast cells was determined. Compounds 31, 32, 35, and 37 showed high selective anticancer activity against breast cancer cells and were also tested against another common type of cancer, non-small cell lung cancer (A549 lung cancer cells versus MRC-5 lung normal cells). Compounds 35 and 37 also showed selectivity against lung cancer cells. These results suggest that compounds 35 and 37 may be promising hit compounds for the development of new anticancer agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha