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Preparation and Activity of Hemostatic and Antibacterial Dressings with Greige Cotton/Zeolite Formularies Having Silver and Ascorbic Acid Finishes.
Edwards, J Vincent; Prevost, Nicolette T; Hinchliffe, Doug J; Nam, Sunghyun; Chang, SeChin; Hron, Rebecca J; Madison, Crista A; Smith, Jade N; Poffenberger, Chelsie N; Taylor, Michelle M; Martin, Erika J; Dixon, Kirsty J.
Afiliação
  • Edwards JV; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Prevost NT; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Hinchliffe DJ; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Nam S; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Chang S; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Hron RJ; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Madison CA; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Smith JN; Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, New Orleans, LA 70124, USA.
  • Poffenberger CN; Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Taylor MM; Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Martin EJ; Department of Internal Medicine, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Dixon KJ; Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Int J Mol Sci ; 24(23)2023 Dec 04.
Article em En | MEDLINE | ID: mdl-38069435
The need for prehospital hemostatic dressings that exert an antibacterial effect is of interest for prolonged field care. Here, we consider a series of antibacterial and zeolite formulary treatment approaches applied to a cotton-based dressing. The design of the fabric formulations was based on the hemostatic dressing TACGauze with zeolite Y incorporated as a procoagulant with calcium and pectin to facilitate fiber adherence utilizing silver nanoparticles, and cellulose-crosslinked ascorbic acid to confer antibacterial activity. Infra-red spectra were employed to characterize the chemical modifications on the dressings. Contact angle measurements were employed to document the surface hydrophobicity of the cotton fabric which plays a role in the contact activation of the coagulation cascade. Ammonium Y zeolite-treated dressings initiated fibrin equal to the accepted standard hemorrhage control dressing and showed similar improvement with antibacterial finishes. The antibacterial activity of cotton-based technology utilizing both citrate-linked ascorbate-cellulose conjugate analogs and silver nanoparticle-embedded cotton fibers was observed against Staphylococcus aureus and Klebsiella pneumoniae at a level of 99.99 percent in the AATCC 100 assay. The hydrogen peroxide levels of the ascorbic acid-based fabrics, measured over a time period from zero up to forty-eight hours, were in line with the antibacterial activities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemostáticos / Zeolitas / Nanopartículas Metálicas Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemostáticos / Zeolitas / Nanopartículas Metálicas Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos