Association of prenatal exposure to PM2.5 and NO2 with gestational diabetes in Western New York.
Environ Res
; 244: 117873, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38072106
ABSTRACT
BACKGROUND:
Although many studies have examined the association between prenatal air pollution exposure and gestational diabetes (GDM), the relevant exposure windows remain inconclusive. We aim to examine the association between preconception and trimester-specific exposure to PM2.5 and NO2 and GDM risk and explore modifying effects of maternal age, pre-pregnancy body mass index (BMI), smoking, exercise during pregnancy, race and ethnicity, and neighborhood disadvantage.METHODS:
Analyses included 192,508 birth records of singletons born to women without pre-existing diabetes in Western New York, 2004-2016. Daily PM2.5 and NO2 at 1-km2 grids were estimated from ensemble-based models. We assigned each birth with exposures averaged in preconception and each trimester based on residential zip-codes. We used logistic regression to examine the associations and distributed lag models (DLMs) to explore the sensitive windows by month. Relative excess risk due to interaction (RERI) and multiplicative interaction terms were calculated.RESULTS:
GDM was associated with PM2.5 averaged in the first two trimesters (per 2.5 µg/m3 OR = 1.08, 95% CI 1.01, 1.14) or from preconception to the second trimester (per 2.5 µg/m3 OR = 1.10, 95% CI 1.03, 1.18). NO2 exposure during each averaging period was associated with GDM risk (per 10 ppb, preconception OR = 1.10, 95% CI 1.06, 1.14; first trimester OR = 1.12, 95% CI 1.08, 1.16; second trimester OR = 1.10, 95% CI 1.06, 1.14). In DLMs, sensitive windows were identified in the 5th and 6th gestational months for PM2.5 and one month before and three months after conception for NO2. Evidence of interaction was identified for pre-pregnancy BMI with PM2.5 (P-for-interaction = 0.023; RERI = 0.21, 95% CI 0.10, 0.33) and with NO2 (P-for-interaction = 0.164; RERI = 0.16, 95% CI 0.04, 0.27).CONCLUSION:
PM2.5 and NO2 exposure may increase GDM risk, and sensitive windows may be the late second trimester for PM2.5 and periconception for NO2. Women with higher pre-pregnancy BMI may be more susceptible to exposure effects.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Diabetes Gestacional
/
Poluentes Atmosféricos
/
Poluição do Ar
Limite:
Female
/
Humans
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos