Liberation of host heme by Clostridioides difficile-mediated damage enhances Enterococcus faecalis fitness during infection.
mBio
; 15(1): e0165623, 2024 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-38078767
ABSTRACT
IMPORTANCE Clostridioides difficile and Enterococcus faecalis are two pathogens of great public health importance. Both bacteria colonize the human gastrointestinal tract where they are known to interact in ways that worsen disease outcomes. We show that the damage associated with C. difficile infection (CDI) releases nutrients that benefit E. faecalis. One particular nutrient, heme, allows E. faecalis to use oxygen to generate energy and grow better in the gut. Understanding the mechanisms of these interspecies interactions could inform therapeutic strategies for CDI.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clostridioides difficile
/
Infecções por Clostridium
/
Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Revista:
MBio
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos