Synthesis of Three-Dimensional Ring Fused Heterocycles by a Selective [4 + 2] Cycloaddition Between Bicyclic Thiazolo 2-Pyridones and Arynes.

Sarkar, Souvik; Singh, Pardeep; Edin, Simon; Wendt, Ola F; Almqvist, Fredrik

Sarkar, Souvik; Singh, Pardeep; Edin, Simon; Wendt, Ola F; Almqvist, Fredrik.

Afiliação

Sarkar S; Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Singh P; Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Edin S; Centre for Analysis and Synthesis, Lund University, SE-221 00 Lund, Sweden.
Wendt OF; Centre for Analysis and Synthesis, Lund University, SE-221 00 Lund, Sweden.
Almqvist F; Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

J Org Chem ; 89(1): 731-739, 2024 Jan 05.

Article em En | MEDLINE | ID: mdl-38093677

ABSTRACT

ABSTRACT

A selective [4 + 2] cycloaddition reaction of thiazolo-2-pyridones with arynes has been demonstrated. The developed protocol allows rapid access to highly functionalized, structurally complex thiazolo-fused bridged isoquinolones in high yields, which are susceptible to further late-stage functionalization.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suécia

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