Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis.

Bailey-Elkin, Ben A; Knaap, Robert C M; De Silva, Anuradha; Boekhoud, Ilse M; Mous, Sandra; van Vught, Niek; Khajehpour, Mazdak; van den Born, Erwin; Kikkert, Marjolein; Mark, Brian L

Bailey-Elkin, Ben A; Knaap, Robert C M; De Silva, Anuradha; Boekhoud, Ilse M; Mous, Sandra; van Vught, Niek; Khajehpour, Mazdak; van den Born, Erwin; Kikkert, Marjolein; Mark, Brian L.

Afiliação

Bailey-Elkin BA; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Knaap RCM; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands.
De Silva A; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Boekhoud IM; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands.
Mous S; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands.
van Vught N; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands.
Khajehpour M; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada.
van den Born E; MSD Animal Health, Boxmeer, The Netherlands.
Kikkert M; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands.
Mark BL; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

PLoS Pathog ; 19(12): e1011872, 2023 Dec.

Article em En | MEDLINE | ID: mdl-38096325

Assuntos

Equartevirus; Vírus da Síndrome Respiratória e Reprodutiva Suína; Animais; Cavalos; Suínos; Humanos; Papaína/química; Papaína/genética; Papaína/metabolismo; Vírus da Síndrome Respiratória e Reprodutiva Suína/genética; Vírus da Síndrome Respiratória e Reprodutiva Suína/metabolismo; Mutagênese; Peptídeo Hidrolases/genética; Replicação Viral; Interferons/genética; Proteínas não Estruturais Virais/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Equartevirus / Vírus da Síndrome Respiratória e Reprodutiva Suína Limite: Animals / Humans Idioma: En Revista: PLoS Pathog Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

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