Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma.
Oncol Rep
; 51(2)2024 02.
Article
em En
| MEDLINE
| ID: mdl-38099422
ABSTRACT
Hypopharyngeal squamous cell carcinoma (HSCC) is a relatively rare form of head and neck cancer that is notorious for its poor prognosis and low overall survival rate. This highlights the need for new therapeutic options for this malignancy. The objective of the present study was to examine the ability of caffeic acid phenethyl ester (CAPE), which is an active compound found in propolis, to combat HSCC tumor growth. CAPE exerted its tumorsuppressive activity in HSCC cell lines through the induction of apoptosis. Mechanistically, the CAPEmediated apoptotic process was attributed to the perturbation of the mitochondrial membrane potential and the activation of caspase9. CAPE also modulated survivin and Xlinked inhibitor of apoptosis, which are potent members of the inhibitors of apoptosis protein family, either through transcriptional or posttranslational regulation, leading to HSCC cell line death. Therefore, the findings of the present study suggested that CAPE is an effective treatment alternative for HSCC via the stimulation of mitochondriadependent apoptosis.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Álcool Feniletílico
/
Neoplasias de Cabeça e Pescoço
Limite:
Humans
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article