Association between serum PCSK9 and coronary heart disease in patients with type 2 diabetes mellitus.
Diabetol Metab Syndr
; 15(1): 260, 2023 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-38115042
ABSTRACT
BACKGROUND AND AIMS:
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered a new biomarker for atherosclerosis, but its ability to predict cardiovascular outcomes has been controversial. This study aimed to address the lack of data on PCSK9, coronary heart disease (CHD) severity, and major cardiovascular events (MACEs) in patients with type 2 diabetes mellitus (T2DM).METHODS:
A total of 2984 T2DM patients underwent selective coronary angiography, and their serum PCSK9 levels were measured using enzyme-linked immunosorbent assay. Correlation and logistic regression analyses were performed to investigate the association between PCSK9 expression and CHD severity. This study used Cox regression analysis to assess the association between circulating PCSK9 levels and the risk of MACEs.RESULTS:
Circulating PCSK9 levels were significantly higher in the CHD group than in the non-CHD group [554.62 (265.11) ng/mL vs. 496.86 (129.05) ng/mL, p < 0.001]. Circulating PCSK9 levels positively correlated with CHD severity (diseased vessels r = 0.35, p < 0.001; Gensini score r = 0.46, p < 0.001). Elevated PCSK9 levels are an independent risk factor for CHD risk and severity (CHD group vs. non-CHD group OR = 2.829, 95% CI 1.771-4.520, p < 0.001; three vessel disease group vs. one vessel disease group OR = 4.800, 95% CI 2.387-9.652, p < 0.001; high GS group vs. low GS group OR = 5.534, 95% CI 2.733-11.208, p < 0.001). Through a six-year follow-up and multivariate Cox regression analysis, elevated circulating PCSK9 levels were found to be independently associated with MACEs in all participants (HR 3.416, 5% CI 2.485-4.697, p < 0.001; adjusted HR 2.780, 95% CI 1.930-4.004, p < 0.001).CONCLUSIONS:
Serum PCSK9 levels were positively correlated with multi-vessel CHD and Gensini score. Elevated circulating PCSK9 levels are an independent risk factor for CHD and increased incidence of MACEs in T2DM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Diabetol Metab Syndr
Ano de publicação:
2023
Tipo de documento:
Article