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The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section.
Hickok, Noreen J; Li, Bingyun; Oral, Ebru; Zaat, Sebastian A J; Armbruster, David A; Atkins, Gerald J; Chen, Antonia F; Coraça-Huber, Débora C; Dai, Tianhong; Greenfield, Edward M; Kasinath, Rajendra; Libera, Matthew; Marques, Cláudia N H; Moriarty, T Fintan; Scott Phillips, K; Raghuraman, Kapil; Ren, Dacheng; Rimondini, Lia; Saeed, Kordo; Schaer, Thomas P; Schwarz, Edward M; Spiegel, Christopher; Stoodley, Paul; Truong, Vi Khanh; Tsang, Shao-Ting Jerry; Wildemann, Britt; Zelmer, Anja R; Zinkernagel, Annelies S.
Afiliação
  • Hickok NJ; Department of Orthopaedic Surgery, Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Li B; Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia, USA.
  • Oral E; Harris Orthopaedic Laboratory, Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Zaat SAJ; Department of Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Armbruster DA; DePuy Synthes Biomaterials, West Chester, Pennsylvania, USA.
  • Atkins GJ; Centre for Orthopaedic and Trauma Research, University of Adelaide, Adelaide, South Australia, Australia.
  • Chen AF; Department of Orthopaedics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Coraça-Huber DC; Research Laboratory for Implant Associated Infections (Biofilm Lab), University Hospital for Orthopedics and Traumatology, Experimental Orthopaedics, Medical University of Innsbruck, Innsbruck, Austria.
  • Dai T; Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Greenfield EM; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indiana Center for Musculoskeletal Health, Indianapolis, Indiana, USA.
  • Kasinath R; DePuy Synthes Biomaterials, Warsaw, Indiana, USA.
  • Libera M; Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, New Jersey, USA.
  • Marques CNH; Department of Biological Sciences, Binghamton Biofilm Research Center, Binghamton University, Binghamton, New York, USA.
  • Moriarty TF; AO Research Institute Davos, Davos, Switzerland.
  • Scott Phillips K; Laboratory of Analytical Chemistry, Division of Biological Standards and Quality Control, Office of Compliance and Biologics Quality, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Raghuraman K; Enovis, Austin, Texas, USA.
  • Ren D; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York, USA.
  • Rimondini L; Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
  • Saeed K; University Hospital Southampton NHS Foundation Trust, Winchester and Basingstoke, UK.
  • Schaer TP; University of Southampton, Southampton, UK.
  • Schwarz EM; Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
  • Spiegel C; Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
  • Stoodley P; Research Laboratory for Biofilms and Implant Associated Infections (BIOFILM LAB), Experimental Orthopedics, University Hospital for Orthopedics and Traumatology, Medical University of Innsbruck, Innsbruck, Austria.
  • Truong VK; Department Microbial Infection and Immunity and Department of Orthopaedics, The Ohio State University, Columbus, Ohio, USA.
  • Tsang SJ; Biomedical Nanoengineering Laboratory, College of Medicine and Public Health, Bedford Park, South Australia, Australia.
  • Wildemann B; Department of Trauma and Orthopaedic Surgery, University of Edinburgh, Edinburgh, Scotland, UK.
  • Zelmer AR; Experimental Trauma Surgery, Department of Trauma, Hand and Reconstructive Surgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
  • Zinkernagel AS; Centre for Orthopaedic and Trauma Research, University of Adelaide, Adelaide, South Australia, Australia.
J Orthop Res ; 42(3): 512-517, 2024 03.
Article em En | MEDLINE | ID: mdl-38146070
ABSTRACT
Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of the internet vote. Only two questions received a ≥90% consensus vote, emphasizing the disparate approaches and lack of established consensus for in vitro modeling and interpretation of results. Comments on knowledge gaps and the need for further research on these critical MSKI questions are included.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biofilmes Idioma: En Revista: J Orthop Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biofilmes Idioma: En Revista: J Orthop Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos