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YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths.
Lin, Jiebo; Zhan, Guankai; Liu, Jinfeng; Maimaitiyiming, Yasen; Deng, Zhiping; Li, Baohua; Su, Kunhui; Chen, Jiafeng; Sun, Siqi; Zheng, Wanlin; Yu, Xianghui; He, Feng; Cheng, Xiaodong; Wang, Lingfang; Shen, Bin; Yao, Ziqin; Yang, Xinquan; Zhang, Jian; He, Wentao; Wu, Hengyu; Naranmandura, Hua; Chang, Kao-Jung; Min, Junxia; Ma, Jun; Björklund, Mikael; Xu, Peng-Fei; Wang, Fudi; Hsu, Chih-Hung.
Afiliação
  • Lin J; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Zhan G; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • Liu J; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Maimaitiyiming Y; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • Deng Z; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Li B; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • Su K; The Second Affiliated Hospital, School of Public Health, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou 310058.
  • Chen J; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Sun S; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • Zheng W; Department of Hematology of First Affiliated Hospital, and Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310000.
  • Yu X; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310000.
  • He F; Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310000.
  • Cheng X; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Wang L; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • Shen B; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Yao Z; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • Yang X; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Zhang J; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • He W; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310000.
  • Wu H; Zhejiang Provincial Key Lab of Genetic and Developmental Disorders, Hangzhou 310058.
  • Naranmandura H; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310000.
  • Chang KJ; Zhejiang Provincial Key Lab of Genetic and Developmental Disorders, Hangzhou 310058.
  • Min J; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
  • Ma J; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310000.
  • Björklund M; Zhejiang Provincial Key Lab of Genetic and Developmental Disorders, Hangzhou 310058.
  • Xu PF; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310000.
  • Wang F; Women's Hospital, The Fourth Affiliated Hospital, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310006.
  • Hsu CH; Institute of Genetics, International School of Medicine, Zhejiang University, Yiwu 322000.
Natl Sci Rev ; 10(12): nwad227, 2023 Dec.
Article em En | MEDLINE | ID: mdl-38152479
ABSTRACT
N6-methyladenosine (m6A) is a critical regulator in the fate of RNA, but whether and how m6A executes its functions in different tissues remains largely obscure. Here we report downregulation of a crucial m6A reader, YTHDF2, leading to tissue-specific programmed cell deaths (PCDs) upon fluorene-9-bisphenol (BHPF) exposure. Currently, Bisphenol A (BPA) substitutes are widely used in plastic manufacturing. Interrogating eight common BPA substitutes, we detected BHPF in 14% serum samples of pregnant participants. In a zebrafish model, BHPF caused tissue-specific PCDs triggering cardiac and vascular defects. Mechanistically, BHPF-mediated downregulation of YTHDF2 reduced YTHDF2-facilitated translation of m6A-gch1 for cardiomyocyte ferroptosis, and decreased YTHDF2-mediated m6A-sting1 decay for caudal vein plexus (CVP) apoptosis. The two distinct YTHDF2-mediated m6A regulations and context-dependent co-expression patterns of gch1/ythdf2 and tnfrsf1a/ythdf2 contributed to YTHDF2-mediated tissue-specific PCDs, uncovering a new layer of PCD regulation. Since BHPF/YTHDF2-medaited PCD defects were also observed in mammals, BHPF exposure represents a potential health threat.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Natl Sci Rev Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Natl Sci Rev Ano de publicação: 2023 Tipo de documento: Article