Effects of preceding antiplatelet agents on severity of ischemic stroke in patients with a history of stroke.
J Neurol Sci
; 456: 122857, 2024 01 15.
Article
em En
| MEDLINE
| ID: mdl-38154249
ABSTRACT
INTRODUCTION:
Antiplatelet agents are effective for secondary prevention of ischemic stroke and can reduce the severity of first-ever ischemic stroke. However, it is uncertain if prophylactic antiplatelet therapy reduces the severity of recurrent ischemic stroke. The aim of this study was to determine the effect of preceding antiplatelet treatment on the severity of thrombotic stroke (TS) in patients with a prior history of stroke.METHODS:
From a prospective hospital registry of 1338 consecutive patients with acute ischemic stroke, we identified patients with a prior history of stroke who were admitted for cardioembolic stroke (CE); TS including large-artery atherosclerosis, small vessel occlusion, and branch atheromatous disease; or other cause or cryptogenic stroke (OCS). Cases in each subtype were categorized based on preceding medication antiplatelet agents (AP) and none (N). Severity of stroke (National Institutes of Health Stroke Scale NIHSS) on admission was compared between AP and N cases.RESULTS:
The total cohort of 252 patients included 83 with CE, 102 with TS, and 67 with OCS. After excluding those with prior anticoagulants, the median NIHSS on admission was lower in AP cases than in N cases (3 vs. 5, p = 0.002). In multivariate analysis, preceding AP treatment was independently associated with minor stroke (NIHSS ≤4) on admission in CE group (OR 8.48, 95% CI 1.71-62.9, p = 0.008) and TS group (OR 4.24, 95% CI 1.44-13.4, p = 0.009).CONCLUSION:
Preceding antiplatelet treatment in patients with a prior history of stroke may reduce the severity of subsequent thrombotic and cardiogenic stroke.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isquemia Encefálica
/
Acidente Vascular Cerebral
/
AVC Isquêmico
Limite:
Humans
Idioma:
En
Revista:
J Neurol Sci
/
J. neurol. sci
/
Journal of the neurological sciences
Ano de publicação:
2024
Tipo de documento:
Article