Prevention strategies for vasovagal reaction in whole blood donors: A quadri-armed randomised control trial.
Transfus Med
; 34(1): 20-29, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38165089
ABSTRACT
INTRODUCTION:
Vasovagal reaction (VVR) is a frequently encountered generalised donor adverse reaction, associated with donor deterrence towards future donation. Several mitigation strategies for prevention of VVR were tried but still not standardised. This quadri-armed randomised study evaluated the utility of water ingestion, applied muscle tension (AMT) and combination of both in preventing the VVR among blood donors.METHODS:
A quadri-armed randomised controlled trial was performed on 4320 whole blood donors. Blood donors of 18-65 years of age were randomised into four groups based on the interventions performed i.e., control with no intervention (Group 1, n = 1081), water ingestion (Group 2, n = 1082), AMT (Group 3, n = 1070) and combined intervention (Group 4, n = 1087). VVR during and immediately after blood donation were observed along with assessment of risk factors in blood donors and the effectiveness of interventions were analysed.RESULTS:
The incidence of VVR observed 1.6% in our study, with the highest occurrence in the control group (2.5%) and the lowest in the combined intervention group (0.9%). Multivariable logistic regression revealed that the control group donors faced a 1.38-fold greater risk of VVR compared to those receiving interventions (OR 1.38, 95% CI 1.10-1.75). Other risk factors included younger age (OR 1.5, 95% CI 1.05-2.17), first-time donation (OR 5.7, 95% CI 1.66-5.74), prior history of VVR (OR 2.5, 95% CI 10.4-101.52). DISCUSSION/CONCLUSION:
The combined approach of water ingestion and AMT proved significantly more effective in VVR prevention compared to individual interventions.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Doadores de Sangue
/
Síncope Vasovagal
/
Estrobilurinas
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Transfus Med
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia