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Change in abdominal obesity after colon cancer surgery - effects of left-sided and right-sided colonic resection.
Kays Mohammed Ali, Younes; Dolin, Troels Gammeltoft; Damm Nybing, Janus; Lykke, Jakob; Hvid Linden, Frederik; Høgh-Schmidt, Erik; Sørensen, Thorkild I A; Christensen, Jesper Frank; Nielsen, Yousef J W; Stenfatt Larsen, Jim; Madsbad, Sten; Sidenius Johansen, Julia; Svane, Maria Saur; Lang Lehrskov, Louise.
Afiliação
  • Kays Mohammed Ali Y; Department of Endocrinological Research, Copenhagen University Hospital -Amager and Hvidovre, Hvidovre, Denmark.
  • Dolin TG; Department of Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Damm Nybing J; Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
  • Lykke J; CopenAge, Copenhagen Center for Clinical Age Research, University of Copenhagen, Copenhagen, Denmark.
  • Hvid Linden F; Department of Radiology, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark.
  • Høgh-Schmidt E; Department of Surgery, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
  • Sørensen TIA; Department of Radiology, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark.
  • Christensen JF; Department of Radiology, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark.
  • Nielsen YJW; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
  • Stenfatt Larsen J; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Madsbad S; Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences at the University of Southern Denmark, Odense, Denmark.
  • Sidenius Johansen J; Digestive Disease Center, Bispebjerg Hospital, Copenhagen, Denmark.
  • Svane MS; Department of Radiology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
  • Lang Lehrskov L; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Int J Obes (Lond) ; 48(4): 533-541, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38172335
ABSTRACT

BACKGROUND:

Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots. MATERIAL AND

METHODS:

Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately.

RESULTS:

A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI 2-9%, p < 0.01) increase in abdominal VAT, a 4% (95% CI 2-6%, p < 0.001) increase in SAT and a 5% increase (95% CI 2-7%, p < 0.01) in TAT. Patients who had undergone right-sided colonic resection had no change in VAT, but a 6% (95% CI 4-9%, p < 0.001) increase in SAT and a 4% (95% CI 1-7%, p < 0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significant VAT increase of 6% (95% CI 2-10%, p < 0.01) after 3 years.

CONCLUSION:

After 3 years follow-up survivors of CC accumulated abdominal adipose tissue. Notably, those who underwent left-sided colonic resection had increased VAT and SAT, whereas those who underwent right-sided colonic resection demonstrated solely increased SAT.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Obesidade Abdominal Limite: Female / Humans / Male Idioma: En Revista: Int J Obes (Lond) Assunto da revista: METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Obesidade Abdominal Limite: Female / Humans / Male Idioma: En Revista: Int J Obes (Lond) Assunto da revista: METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Dinamarca