Aldose reductase is a potential therapeutic target for neurodegeneration.
Chem Biol Interact
; 389: 110856, 2024 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-38185272
ABSTRACT
Neurodegeneration is a complex process involving various inflammatory mediators and cellular responses. Aldose reductase (AR) is a key enzyme in the polyol pathway, which converts glucose to sorbitol. Beyond its metabolic role, AR has also been found to play a significant role in modulating neuroinflammation. This review aims to provide an overview of the current knowledge regarding the involvement of AR inhibition in attenuating neuroinflammation and complications from diabetic neuropathies. Here, we review the literature regarding AR and neuropathy/neurodegeneration. We discuss the mechanisms underlying the influence of AR inhibitors on ocular inflammation, beta-amyloid-induced neurodegeneration, and optic nerve degeneration. Furthermore, potential therapeutic strategies targeting AR in neurodegeneration are explored. The understanding of AR's role in neurodegeneration may lead to the development of novel therapeutic interventions for other neuroinflammatory disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aldeído Redutase
/
Neuropatias Diabéticas
Limite:
Humans
Idioma:
En
Revista:
Chem Biol Interact
/
Chem. biol. interact
/
Chemico-biological interactions
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos