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Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.
Ho, Pei-Chuan; Yu, Wai Haung; Tee, Boon Lead; Lee, Wan-Ping; Li, Clara; Gu, Yian; Yokoyama, Jennifer S; Reyes-Dumeyer, Dolly; Choi, Yun-Beom; Yang, Hyun-Sik; Vardarajan, Badri N; Tzuang, Marian; Lieu, Kevin; Lu, Anna; Faber, Kelley M; Potter, Zoë D; Revta, Carolyn; Kirsch, Maureen; McCallum, Jake; Mei, Diana; Booth, Briana; Cantwell, Laura B; Chen, Fangcong; Chou, Sephera; Clark, Dewi; Deng, Michelle; Hong, Ting Hei; Hwang, Ling-Jen; Jiang, Lilly; Joo, Yoonmee; Kang, Younhee; Kim, Ellen S; Kim, Hoowon; Kim, Kyungmin; Kuzma, Amanda B; Lam, Eleanor; Lanata, Serggio C; Lee, Kunho; Li, Donghe; Li, Mingyao; Li, Xiang; Liu, Chia-Lun; Liu, Collin; Liu, Linghsi; Lupo, Jody-Lynn; Nguyen, Khai; Pfleuger, Shannon E; Qian, James; Qian, Winnie; Ramirez, Veronica.
Afiliação
  • Ho PC; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Yu WH; The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Tee BL; Brain Health and Imaging Center and Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Lee WP; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Li C; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Gu Y; Global Brain Health Institute, University of California, San Francisco, San Francisco, California, USA.
  • Yokoyama JS; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Reyes-Dumeyer D; Alzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Choi YB; Department of Neurology, Columbia University Medical Center, New York, New York, USA.
  • Yang HS; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Vardarajan BN; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
  • Tzuang M; Gertrude H. Sergievsky Center, Taub Institute of Aging Brain and Department of Neurology at Columbia University, New York, New York, USA.
  • Lieu K; Englewood Health, Englewood, New Jersey, USA.
  • Lu A; Department of Neurology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Faber KM; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Potter ZD; Harvard Medical School, Boston, Massachusetts, USA.
  • Revta C; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Kirsch M; Gertrude H. Sergievsky Center, Taub Institute of Aging Brain and Department of Neurology at Columbia University, New York, New York, USA.
  • McCallum J; Department of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA.
  • Mei D; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Booth B; Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
  • Cantwell LB; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Chen F; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Chou S; Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
  • Clark D; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Deng M; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Hong TH; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Hwang LJ; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Jiang L; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Joo Y; Department of Neurology, Columbia University Medical Center, New York, New York, USA.
  • Kang Y; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Kim ES; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Kim H; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Kim K; University of Southern California, Los Angeles, California, USA.
  • Kuzma AB; Stanford Alzheimer's Disease Research Center, Stanford, California, USA.
  • Lam E; University of Southern California, Los Angeles, California, USA.
  • Lanata SC; Department of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA.
  • Lee K; College of Nursing, Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Republic of Korea.
  • Li D; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Li M; Department of Neurology, Chosun University Hospital, Dong-gu, Gwangju, Republic of Korea.
  • Li X; Department of Child Development and Family Studies, College of Human Ecology, Seoul National University, Jongno-gu, Seoul, Republic of Korea.
  • Liu CL; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Liu C; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Liu L; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Lupo JL; Biomedical Science, College of Natural Sciences, Chosun University, Gwanak-gu, Seoul, Republic of Korea.
  • Nguyen K; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.
  • Pfleuger SE; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Qian J; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Qian W; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Ramirez V; Department of Neurology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA.
Alzheimers Dement ; 20(3): 2058-2071, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38215053
ABSTRACT

INTRODUCTION:

Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population.

METHODS:

The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.

RESULTS:

ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception.

DISCUSSION:

ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. HIGHLIGHTS The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / População Norte-Americana Tipo de estudo: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Alzheimers Dement Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / População Norte-Americana Tipo de estudo: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Alzheimers Dement Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos