Interplay between the transcription preinitiation complex and the +1 nucleosome.
Trends Biochem Sci
; 49(2): 145-155, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-38218671
ABSTRACT
Eukaryotic transcription starts with the assembly of a preinitiation complex (PIC) on core promoters. Flanking this region is the +1 nucleosome, the first nucleosome downstream of the core promoter. While this nucleosome is rich in epigenetic marks and plays a key role in transcription regulation, how the +1 nucleosome interacts with the transcription machinery has been a long-standing question. Here, we summarize recent structural and functional studies of the +1 nucleosome in complex with the PIC. We specifically focus on how differently organized promoter-nucleosome templates affect the assembly of the PIC and PIC-Mediator on chromatin and result in distinct transcription initiation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Nucleossomos
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China