Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.
Hypertension
; 81(3): 552-560, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38226488
ABSTRACT
BACKGROUND:
The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.METHODS:
We analyzed up to 9â 420â 585 single nucleotide polymorphisms in up to 127â 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (n=35â 660) and UK Biobank (n=91â 622) and performed European population-specific and cross-population meta-analyses.RESULTS:
We identified 3 loci in European-specific analyses and an additional 4 loci in cross-population analyses at Pinteraction<5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency, 0.03) and the DASH diet score (Pinteraction=4e-8; P for heterogeneity, 0.35) in European population, where the interaction effect size was 0.42±0.09 mmâ Hg (Pinteraction=9.4e-7) and 0.20±0.06 mmâ Hg (Pinteraction=0.001) in Cohorts for Heart and Aging Research in Genomic Epidemiology and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants (P=4e-273) and cis-DNA methylation quantitative trait loci variants (P=1e-300). Although the closest gene for rs117878928 is MTHFS, the highest narrow sense heritability accounted by single nucleotide polymorphisms potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1.CONCLUSIONS:
We demonstrated gene-DASH diet score interaction effects on systolic BP in several loci. Studies with larger diverse populations are needed to validate our findings.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Abordagens Dietéticas para Conter a Hipertensão
/
Hipertensão
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Hypertension
Ano de publicação:
2024
Tipo de documento:
Article