Alcohol synthesis based on the S<sub>N</sub>2 reactions of alkyl halides with the squarate dianion.

Sato, Kazuto; Fujita, Tomoyuki; Takeuchi, Takashi; Suzuki, Takahiro; Ikeuchi, Kazutada; Tanino, Keiji

Alcohol synthesis based on the S_N2 reactions of alkyl halides with the squarate dianion.

Sato, Kazuto; Fujita, Tomoyuki; Takeuchi, Takashi; Suzuki, Takahiro; Ikeuchi, Kazutada; Tanino, Keiji.

Afiliação

Sato K; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan.
Fujita T; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan.
Takeuchi T; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan.
Suzuki T; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. ktanino@sci.hokudai.ac.jp.
Ikeuchi K; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. ktanino@sci.hokudai.ac.jp.
Tanino K; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. ktanino@sci.hokudai.ac.jp.

Org Biomol Chem ; 22(7): 1369-1373, 2024 Feb 14.

Article em En | MEDLINE | ID: mdl-38232248

ABSTRACT

ABSTRACT

A convenient method has been developed for transforming alkyl halides into the corresponding alcohols via an SN2 reaction. Treatment of an alkyl halide with the squarate dianion at high temperature produces mono-alkyl squarate, and a one-pot basic hydrolysis of the intermediate affords the alcohol in good yield.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

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