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Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome.
NaveenKumar, Somanathapura K; Tambralli, Ajay; Fonseca, Bruna Mazetto; Yalavarthi, Srilakshmi; Liang, Wenying; Hoy, Claire K; Sarosh, Cyrus; Rysenga, Christine E; Ranger, Caroline H; Vance, Caroline E; Madison, Jacqueline A; Orsi, Fernanda A; Sood, Suman L; Schaefer, Jordan K; Zuo, Yu; Knight, Jason S.
Afiliação
  • NaveenKumar SK; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Tambralli A; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Fonseca BM; Division of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
  • Yalavarthi S; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Liang W; Hematology and Hemotherapy Center, Department of Pathology, University of Campinas, Campinas, Brazil.
  • Hoy CK; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Sarosh C; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Rysenga CE; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Ranger CH; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Vance CE; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Madison JA; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Orsi FA; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Sood SL; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Schaefer JK; Division of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
  • Zuo Y; Hematology and Hemotherapy Center, Department of Pathology, University of Campinas, Campinas, Brazil.
  • Knight JS; Division of Hematology & Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Blood ; 143(12): 1193-1197, 2024 Mar 21.
Article em En | MEDLINE | ID: mdl-38237140
ABSTRACT
ABSTRACT Many patients with antiphospholipid syndrome had decreased ectonucleotidase activity on neutrophils and platelets, which enabled extracellular nucleotides to trigger neutrophil-platelet aggregates. This phenotype was replicated by treating healthy neutrophils and platelets with patient-derived antiphospholipid antibodies or ectonucleotidase inhibitors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Antifosfolipídica Limite: Humans Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Antifosfolipídica Limite: Humans Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article