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SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications - review article.
Feng, Dechao; Wang, Jie; Xiao, Yuhan; Wu, Ruicheng; Li, Dengxiong; Tuo, Zhouting; Yu, Qingxin; Ye, Luxia; Miyamoto, Akira; Yoo, Koo Han; Wei, Wuran; Ye, Xing; Zhang, Chi; Han, Ping.
Afiliação
  • Feng D; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu.
  • Wang J; Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou.
  • Xiao Y; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu.
  • Wu R; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu.
  • Li D; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu.
  • Tuo Z; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu.
  • Yu Q; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei.
  • Ye L; Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo City, Zhejiang Province.
  • Miyamoto A; Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, People's Republic of China.
  • Yoo KH; Department of Rehabilitation, West Kyushu University, Japan.
  • Wei W; Department of Urology, Kyung Hee University, South Korea.
  • Ye X; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu.
  • Zhang C; Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Han P; Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou.
Int J Surg ; 110(4): 2323-2337, 2024 Apr 01.
Article em En | MEDLINE | ID: mdl-38241327
ABSTRACT
Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore, which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, the authors comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis, and narrative summary. The authors also provided the top 10 predicted drugs targeting SKA3. The authors proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Neoplasias Limite: Humans Idioma: En Revista: Int J Surg Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Neoplasias Limite: Humans Idioma: En Revista: Int J Surg Ano de publicação: 2024 Tipo de documento: Article