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The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target.
Huang, Weichao; Zhang, Zilong; Colucci, Manuel; Deng, Linghui; Yang, Mi; Huang, Xinyi; Zhou, Xianghong; Jin, Yumin; Lazzarini, Edoardo; Balbi, Carolina; Juanola, Oriol; Valdata, Aurora; Bressan, Silvia; Zhan, Yu; Qi, Fang; Wei, Qiang; Yang, Lu; Zou, Xiaoli; Qiu, Shi.
Afiliação
  • Huang W; Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
  • Zhang Z; Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
  • Colucci M; Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland; Università della Svizzera Italiana, CH6900 Lugano, Switzerland; Faculty of Biology and Medicine, University of Lausanne UNIL, CH1011 Lausanne, Switzerland.
  • Deng L; National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China; Department of Gerontology, West China Hospital of Sichuan University, Chengdu, China.
  • Yang M; Department of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Huang X; Department of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Zhou X; Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Jin Y; Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Lazzarini E; Laboratory for Cardiovascular Theranostics, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano Switzerland.
  • Balbi C; Cellular and Molecular Cardiology, Istituto Cardiocentro Ticino, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Center for Molecular Cardiology, Zurich, Switzerland.
  • Juanola O; Gastroenterology and Hepatology, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  • Valdata A; Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland; Università della Svizzera Italiana, CH6900 Lugano, Switzerland; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich, CH, Switzerland.
  • Bressan S; Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland; Università della Svizzera Italiana, CH6900 Lugano, Switzerland.
  • Zhan Y; Department of Environmental Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
  • Qi F; Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, People's Republic of China.
  • Wei Q; Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Yang L; Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: wycleflue@scu.edu.cn.
  • Zou X; Department of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. Electronic address: zouxl_1113@163.com.
  • Qiu S; Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500 Bellinzona, Switzerland. Electronic address: qiushi@scu.edu.cn.
Environ Int ; 184: 108447, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38246039
ABSTRACT

INTRODUCTION:

Although previous studies investigated the potential adverse effects of endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related diseases, the mixed effect of multiple types of EDCs on biological age acceleration, including its potential underlying mechanism, remains unclear.

METHODS:

Data from the National Health and Nutrition Examination Survey (NHANES) were used to analyze biological age measures, including Klemera-Doubal method biological age (KDM-BA), phenotypic age, and homeostatic dysregulation (HD). Weight quantile sum (WQS) regression was performed to screen biological age-related EDCs (BA-EDCs) and assess the mixed effect of BA-EDCs on biological age acceleration and aging-related disease. Targets of BA-EDCs were obtained from three databases, while heart aging-related genes were obtained from the Aging Anno database. Protein-protein interaction (PPI) network and MCODE algorithm were applied to identify potential interactions between BA-EDC targets and heart aging-related genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed to identify related pathways.

RESULTS:

This cross-sectional study included 1,439 participants. A decile increase in BA-EDCs co-exposure was associated with 0.31 years and 0.17 years of KDM-BA and phenotypic age acceleration, respectively. The mixed effect of BA-EDCs was associated with an increased prevalence of atherosclerotic cardiovascular disease (ASCVD). Vitamins C and E demonstrated a significant interaction effect on the association between BA-EDCs and KDM-BA acceleration. PPI network and functional enrichment analysis indicated that the AGE-RAGE signaling pathway in diabetic complications was significantly enriched.

CONCLUSION:

Our results showed that the co-exposure effect of BA-EDCs was associated with biological age acceleration and ASCVD, with the AGE-RAGE signaling pathway being the underlying mechanism. Vitamins C and E may also be an actionable target for preventing EDC-induced biological aging.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disruptores Endócrinos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Environ Int Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disruptores Endócrinos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Environ Int Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China